Axolotls can be used to efficiently screen chemicals for toxicity and effects on tissue regeneration. This database reports chemicals that were screened using an axolotl embryo tail regeneration model. Chemical outcomes on tail regeneration were classified as either inhibitory, non-inhibitory, or toxic, and chemicals that were validated in a second screen are noted. The database can be searched using a chemical's name, structure (SMILES), molecular weight (ML), or bioactivity.
For more details about the chemical screening project, click here.
To learn how to perform the axolotl embryo tail regeneration assay, click here.

Search for Identifier/Chemical Name/Molecular Weight/SMILES/Vendor or Source/Bioactivity:   
Example Query:
Chemical Name = Romidepsin
SMILES = C\C=C1\NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C
MW = 540.69
Bioactivity = Histone deacetylase inhibitor (HDAC)
Outcome = Inhibits tail regeneration at 10 uM
Validated = Yes

Fun Facts

How long does it take for a salamander to regenerate a limb?

The length of time it takes a salamander to regenerate varies in several ways.

As a salamander gets older, its ability to regenerate decreases.

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