Chemical Screening

Chemical Screening

Axolotls can be used to efficiently screen chemicals for toxicity and effects on tissue regeneration. This database reports chemicals that were screened using an axolotl embryo tail regeneration model. Chemical outcomes on tail regeneration were classified as either inhibitory, non-inhibitory, or toxic, and chemicals that were validated in a second screen are noted. The database can be searched using a chemical's name, structure (SMILES), molecular weight (ML), or bioactivity.

To learn how to perform the axolotl embryo tail regeneration assay, see the 2020 Axolotl Newsletter. 

Search for Chemical Name/SMILES/MW/Bioactivity                                                                                                                                                                                                                                                                           

Example Query:

Chemical Name = Romidepsin 

SMILES = C\C=C1\NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C     

MW = 540.69

Bioactivity = Histone deacetylase inhibitor (HDAC)

Outcome = Inhibits tail regeneration at 10 uM

Validated = Yes